Proteomic and lipidomic analysis of low-density lipoprotein identifies potential biomarkers of early estrogen receptor-positive breast cancer
- Published on 05/06/2025
- Reading time: 5 min.
Abu Mohsen Yamama 1,2, Twitto-Greenberg Rachel 1, Cohen Anna 1, Leichner Gil S 1, Mahler Lidor 1,2, Cohen Hofit 1,2, Kamari Yehuda 1,2, Shaish Aviv 1,3, Harari Ayelet 1, Leikin-Frenkel Alicia 1,2, Glick Saar Efrat 4, Geiger Tamar 5, Malitsky Sergey 5, Itkin Maxim 5, Harats Dror 1,2, Keshet Rom 1,2
1 https://ror.org/020rzx487 The Bert W. Strassburger Metabolic Center for Preventive Medicine, Sheba Medical Center Ramat Gan Israel
2 https://ror.org/04mhzgx49 School of Medicine, The Faculty of Medical and Health Sciences Tel-Aviv University Tel-Aviv Israel
3 https://ror.org/024hcay96 Achva Academic College Beer-Tuvia Regional Council Israel
4 https://ror.org/020rzx487 The Wohl Institute for Translational Research Sheba Medical Center Ramat Gan Israel
5 https://ror.org/0316ej306 Weizmann Institute of Science Rehovot Israel
Abstract
Estrogen receptor (ER)-positive breast cancer (BC) is a prevalent and fatal cancer among women, and there is a need to identify molecules involved in the disease pathophysiology which could also serve as biomarkers for early detection. Detection of cancer markers in whole plasma produces excessive information, and identifying important markers involved in cancer progression is challenging. We identified a BC-specific low-density lipoprotein (LDL) particle isolated by ultracentrifugation...
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