Effect of sacubitril/valsartan in heart failure with preserved ejection fraction across the age spectrum in PARAGON‐HF
- Published on 02/03/2025
- Reading time: 5 min.
Xiaowen Wang 1, Orly Vardeny 2, Brian Claggett 1, Muthiah Vaduganathan 1, Sheila M. Hegde 1, Hicham Skali 1, Maria A. Pabon 1, Alberto Foà 1,3, Safia Chatur 1, Annamaria Kosztin 4, Eileen O'Meara 5, Jean Rouleau 5, Margaret Redfield 6, Carolyn S.P. Lam 7, Michael Zile 8, Milton Packer 9,10, Amil M. Shah 11, Maja Cikes 12, Mauro Gori 13, Bela Merkely 4, Marc A. Pfeffer 1, John J.V. McMurray 14, Scott D. Solomon 1
1
Division of Cardiovascular Medicine
Brigham and Women's Hospital
Boston
MA
USA
2
Minneapolis VA Center for Care Delivery and Outcomes Research University of Minnesota
Minneapolis
MN
USA
3
Cardiology Unit, Department of Medical and Surgical Sciences (DIMEC)
Alma Mater Studiorum University of Bologna
Bologna
Italy
4
Semmelweis University Heart and Vascular Center
Budapest
Hungary
5
Universite de Montreal
Montreal
QC
Canada
6
Mayo Clinic
Rochester
MN
USA
7
National Heart Centre Singapore, Duke‐NUS Medical School
Singapore
Singapore
8
Medical University of South Carolina
Carleston
SC
USA
9
Baylor University Medical Center
Dallas
TX
USA
10
Imperial College
London
UK
11
Division of Cardiovascular Medicine
University of Texas Southwestern Medical Center
Dallas
TX
USA
12
University of Zagreb School of Medicine, Department of Cardiovascular Diseases
University Hospital Center Zagreb
Zagreb
Croatia
13
Cardiology Division, Cardiovascular Department
Papa Giovanni XXIII Hospital
Bergamo
Italy
14
British Heart Foundation Cardiovascular Research Centre, University of Glasgow
Glasgow
UK
Abstract
Aims To evaluate clinical outcomes, echocardiographic features, and the efficacy and safety of sacubitril/valsartan compared to valsartan across age groups in the PARAGON‐HF trial.
Methods and results A total of 4796 participants ≥50 years of age with chronic heart failure (HF) and left ventricular ejection fraction (LVEF) ≥45% were divided into three age groups: <65 years (n = 825),...
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