Effect of sacubitril/valsartan in heart failure with preserved ejection fraction across the age spectrum in PARAGON‐HF

  • Published on 02/03/2025
  •  Reading time: 5 min.

Xiaowen Wang 1, Orly Vardeny 2, Brian Claggett 1, Muthiah Vaduganathan 1, Sheila M. Hegde 1, Hicham Skali 1, Maria A. Pabon 1, Alberto Foà 1,3, Safia Chatur 1, Annamaria Kosztin 4, Eileen O'Meara 5, Jean Rouleau 5, Margaret Redfield 6, Carolyn S.P. Lam 7, Michael Zile 8, Milton Packer 9,10, Amil M. Shah 11, Maja Cikes 12, Mauro Gori 13, Bela Merkely 4, Marc A. Pfeffer 1, John J.V. McMurray 14, Scott D. Solomon 1

1 Division of Cardiovascular Medicine Brigham and Women's Hospital Boston MA USA
2 Minneapolis VA Center for Care Delivery and Outcomes Research University of Minnesota Minneapolis MN USA
3 Cardiology Unit, Department of Medical and Surgical Sciences (DIMEC) Alma Mater Studiorum University of Bologna Bologna Italy
4 Semmelweis University Heart and Vascular Center Budapest Hungary
5 Universite de Montreal Montreal QC Canada
6 Mayo Clinic Rochester MN USA
7 National Heart Centre Singapore, Duke‐NUS Medical School Singapore Singapore
8 Medical University of South Carolina Carleston SC USA
9 Baylor University Medical Center Dallas TX USA
10 Imperial College London UK
11 Division of Cardiovascular Medicine University of Texas Southwestern Medical Center Dallas TX USA
12 University of Zagreb School of Medicine, Department of Cardiovascular Diseases University Hospital Center Zagreb Zagreb Croatia
13 Cardiology Division, Cardiovascular Department Papa Giovanni XXIII Hospital Bergamo Italy
14 British Heart Foundation Cardiovascular Research Centre, University of Glasgow Glasgow UK

Abstract

Aims To evaluate clinical outcomes, echocardiographic features, and the efficacy and safety of sacubitril/valsartan compared to valsartan across age groups in the PARAGON‐HF trial.
Methods and results A total of 4796 participants 50 years of age with chronic heart failure (HF) and left ventricular ejection fraction (LVEF) 45% were divided into three age groups: <65 years (n = 825),...

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