Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Published on 06/10/2024

Reading time: 11 min.

Mocci, Giuseppe^,*; Sukhavasi, Katyayani^,*; Ord, Tiit; Bankier, Sean; Singha, Prosanta; Arasu, Uma Thanigai; Agbabiaje, Olayinka Oluwasegun; Makinen, Petri; Ma, Lijiang; Hodonsky, Chani J.; Aherrahrou, Redouane; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Byandelger, Byambajav; Wang, Ying; Koplev, Simon; Lendahl, Urban; Owens, Gary K.; Leeper, Nicholas J.; Pasterkamp, Gerard; Vanlandewijck, Michael; Michoel, Tom; Ruusalepp, Arno; Hao, Ke; Yla-Herttuala, Seppo; Vali, Marika; Jarve, Heli; Mokry, Michal; Civelek, Mete; Miller, Clint J.; Kovacic, Jason C.; Kaikkonen, Minna U.^,+; Betsholtz, Christer^,,+; Bjorkegren, Johan L.M.

Abstract

Background While our understanding of the single-cell gene expression patterns underlying the transformation of vascular cell types during the progression of atherosclerosis is rapidly improving, the clinical and pathophysiological relevance of these changes remains poorly understood.
Methods Single-cell RNA sequencing data generated with SmartSeq2...

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