Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF

Published on 09/02/2024

Reading time: 9 min.

Dewan, Pooja Mbbs, Phd^*,; Shen, Li Mbchb, Phd^*,,; Pedro Ferreira, Joao Phd^*,,; Jhund, Pardeep S.Mbchb, Phd; Anand, Inder S.Md, Dphil; Chandra, Alvin Md; Chiang, Lu-May Phd; Claggett, Brian Phd; Desai, Akshay S.Md, Mph; Gong, Jianjian Phd; Lam, Carolyn S.P.Mbbs, Phd; Lefkowitz, Martin P.Md; Maggioni, Aldo P.Md; Martinez, Felipe Md; Packer, Milton Md; Redfield, Margaret M.Md; Rouleau, Jean L.Md; Van Veldhuisen, Dirk J.Md; Zannad, Faiez Md; Zile, Michael R.Md; Solomon, Scott D.Md; Mcmurray, John J.V.MD

Abstract

Background A hypothetical concern has been raised that sacubitril/valsartan might cause cognitive impairment because neprilysin is one of several enzymes degrading amyloid-[beta] peptides in the brain, some of which are neurotoxic and linked to Alzheimer-type dementia. To address this, we examined the effect of sacubitril/valsartan compared with valsartan on...

To continue reading this article in Full-Text...

Access request*

* Access is totally free, without commitment or condition. Service exclusively reserved for healthcare professionals.

Circulation

Peer-Reviewed Journals A-Z

Search | Advanced search

Get the latest news in Cardiology

Receive our newsletter to stay up to date with the latest news in Cardiology

Access request

From peer-reviewed journals in Cardiology

[space]	Find documents with all the words specified. dopamine homeostasis will get documents with dopamine and homeostasis, found documents must contain the two elements.
OR	Find documents with at least one of the words specified. dopamine OR homeostasis will get documents with word dopamine or homeostasis.
-	The sign - exclude the documents with word or expression specified. dopamine - homeostasis will get the documents with dopamine but without homeostasis. The sign - must be used with others operators.
" "	Find the documents with exactly the expression between the two quotation marks. Example: "symptomatic medication" will find only the documents with "symptomatic medication" in the document.
( )	Brackets are used to group words in a sub expression: (dopamine homeostasis) OR (ergotamine headache)
*	Asterisk is the truncation operator. It can be used as a prefix (with quotation marks) or suffix. *dopa homeo, dopne or "cature"*.