Cell competition in primary and metastatic colorectal cancer

  • Published on 08/01/2024
  •  Reading time: 14 min.

van Luyk Merel Elise , Krotenberg Garcia Ana , Lamprou Maria , Suijkerbuijk Saskia Jacoba Elisabeth

https://ror.org/04pp8hn57 Division of Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology, Faculty of Science Utrecht University Utrecht The Netherlands

Abstract

Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker “loser” cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis. In fact, cell competition plays a crucial role in tumor suppression, through elimination of early malignant cells, as part of Epithelial Defense Against Cancer. However, it is increasingly apparent that cell competition...

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