The impact of KRAS mutations on risk of venous thromboembolism recurrence in patients with metastatic colorectal cancer
- Published on 04/15/2025
- Reading time: 5 min.
Liang Zhikun 1,2, Huang Xiaoyan 1,2, Mao Jieling 1,3, Xie Jingwen 1,2, Li Xiaoyan 1,2,4, Qin Li 1,2,4
1 https://ror.org/0064kty71 Department of Pharmacy, The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou China
2 https://ror.org/0064kty71 Biomedical Innovation Center, The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou China
3 https://ror.org/0064kty71 School of Pharmaceutical Science Sun Yat-sen University Guangzhou China
4 https://ror.org/0064kty71 Department of Pharmacy The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University 26 Erheng Road of Yuan Village, Tianhe District 510655 Guangzhou China
Abstract
Background The relationship between KRAS mutations and the risk of venous thromboembolism (VTE) recurrence in metastatic colorectal cancer (mCRC) patients with established cancer-associated thrombosis (CAT) remains uncertain. This study aims to (1) evaluate the predictive value of seven KRAS mutation subtypes for VTE recurrence and (2) assess the impact of incorporating these mutations into two existing VTE risk scores: the Khorana score and the...
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