Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers

  • Published on 02/03/2025
  •  Reading time: 7 min.

Jin Ping 1, Ma Juan 2, Wu Peng 2, Bian Yitong 3, Ma Xueping 2, Jia Shaobin 2, Zheng Qiangsun 1

1 https://ror.org/03aq7kf18 Department of Cardiology Second Affiliated Hospital of Xi’an Jiaotong University Xi’an Shaanxi China
2 https://ror.org/02h8a1848 Heart Centre & Department of Cardiovascular Diseases General Hospital of Ningxia Medical University Yinchuan Ningxia China
3 https://ror.org/02tbvhh96 Department of Medical Imaging First Affiliated Hospital of Xi’an Jiaotong University Xi’an Shaanxi China

Abstract

Background Homocysteine (Hcy) and the proprotein convertase subtilisin/kexin type 9 (PCSK9) significantly contribute to atherosclerosis (AS) as well as coronary lesion severity. Our previous work demonstrated that Hcy upregulates PCSK9, accelerating lipid accumulation and AS. A PCSK9 antagonist reduces plasma Hcy levels in ApoE−/− mice. These findings suggest complex roles for both Hcy and PCSK9 in AS. This study investigated the mutual mediating...

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