Daily low‐dose aspirin and blood pressure in community‐dwelling older adults

Published on 09/02/2024

Reading time: 4 min.

Michael E. ErnstPharmD ^1,2, Kevin PhanMBiostat³, Mark R. NelsonMBBS, PhD^3,4, Robyn L. WoodsPhD³, Michelle A. FravelPharmD¹, Lawrence BeilinMB, MD⁵, Suzanne G. OrchardPhD³, Zhen ZhouPhD³, Kevan R. PolkinghorneMBChB, PhD^3,6,7, Jonathan C. BroderMStat&OpRes³, Karen L. MargolisMD, MPH⁸, Christopher M. ReidPhD^3,9, Nigel StocksMBBS, MD¹⁰, Enayet ChowdhuryMBBS, MP, PhD^3,11, Rory WolfePhD³

¹ Department of Pharmacy Practice and Science College of Pharmacy, The University of Iowa Iowa City Iowa USA
² Department of Family Medicine Carver College of Medicine, The University of Iowa Iowa City Iowa USA
³ School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia
⁴ Menzies Institute for Medical Research University of Tasmania Hobart Australia
⁵ Medical School Royal Perth Hospital University of Western Australia Perth Western Australia Australia
⁶ Department of Nephrology Monash Medical Centre, Monash Health Melbourne Victoria Australia
⁷ Department of Medicine Monash University Melbourne Victoria Australia
⁸ HealthPartners Institute Minneapolis Minnesota USA
⁹ School of Population Health Curtin University Perth Western Australia Australia
¹⁰ Discipline of General Practice, Adelaide Medical School The University of Adelaide Adelaide South Australia Australia
¹¹ Advara HeartCare Melbourne Victoria Australia

Abstract

High‐quality randomized trial evidence is lacking on whether low‐dose aspirin exerts significant effects on blood pressure (BP) in older adults. The authors assessed longitudinal BP changes in participants enrolled in ASPirin in Reducing Events in the Elderly (ASPREE), a randomized, placebo‐controlled trial of 100 mg daily aspirin in 19 114 community‐dwelling Australian and U.S. adults without cardiovascular disease (CVD), dementia, or independence‐limiting...

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The Journal of Clinical Hypertension

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