Copper in colorectal cancer: From copper‐related mechanisms to clinical cancer therapies

  • Published on 07/04/2024
  •  Reading time: 11 min.

Yuhong Wang1,2,3, Pei Pei4, Kai Yang 3,4, Lingchuan Guo 3, Yuan Li 1,2

1 Department of Pathology Fudan University Shanghai Cancer Center Shanghai China
2 Department of Oncology Shanghai Medical College Fudan University Shanghai China
3 Department of Pathology The First Affiliated Hospital of Soochow University Suzhou China
4 State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD‐X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou Jiangsu China


Copper, a trace element and vital cofactor, plays a crucial role in the maintenance of biological functions. Recent evidence has established significant correlations between copper levels, cancer development and metastasis. The strong redox‐active properties of copper offer both benefits and disadvantages to cancer cells. The intestinal tract, which is primarily responsible for copper uptake and regulation, may suffer from an imbalance in copper homeostasis. Colorectal...


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