Does adjuvant chemotherapy result in poorer health-related quality of life among colorectal cancer patients? A longitudinal multisite observational study in Singapore
- Published on 04/08/2025
- Reading time: 5 min.
Lau Jerrald 1,2, Peh Cherie Hui 1, Ng Alyssa 1, Koh Wei-Ling 1, 3,4,5, The Singapore Colorectal Cancer Research Group, Lieske Bettina 3, Cheong Wai-Kit 3, Ng Jing-Yu 3, Chan Dedrick Kok-Hong 3, Tan Ian Jse-Wei 3, Lee Kai-Yin 3, Buan Bryan 3, Tan Jarrod Kah Hwee 3, Seow Choon-Sheong 4, Keh Christopher Hang-Liang 4, Chew Min-Hoe 5, Foo Fung-Joon 5, Koh Frederick 5, Sivarajah Sharmini Su 5, Tan Winson Jianhong 5, Luo Nan 2, Tan Ker-Kan 1,2,3
1 https://ror.org/01tgyzw49 Department of Surgery Yong Loo Lin School of Medicine, National University of Singapore C/O NUHS Tower Block, Level 8 1E Kent Ridge Road 119228 Singapore Singapore
2 https://ror.org/01tgyzw49 Saw Swee Hock School of Public Health National University of Singapore Singapore Singapore
3 https://ror.org/04fp9fm22 Department of Surgery National University Hospital Singapore Singapore
4 https://ror.org/055vk7b41 Department of General Surgery Ng Teng Fong General Hospital Singapore Singapore
5 https://ror.org/05cqp3018 Department of General Surgery Sengkang General Hospital Singapore Singapore
Abstract
Background Research on health-related quality of life (HRQOL) using minimally important differences for cancer care in Asian settings are sparse. This study aimed to describe functional HRQOL trajectories among Colorectal Cancer (CRC) patients undergoing adjuvant chemotherapy (AC) compared to those who did not (No AC), evaluate if AC was associated with change in HRQOL prospectively, and examine QOL differences between elderly and non-elderly CRC patients requiring...
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