Plasma renin activity as a marker for predicting the antihypertensive effect of switching to sacubitril/valsartan in treated hypertensive patients: Usefulness in daily clinical practice

Published on 01/06/2025

Reading time: 3 min.

Takeshi HorioMD, PhD ¹, Yoshio IwashimaMD, PhD^2,3, Minoru YoshiyamaMD, PhD⁴, Daiju FukudaMD, PhD⁵, Tatemitsu RaiMD, PhD³, Kohei FujimotoMD, PhD¹

¹ Department of Cardiovascular Medicine Ishikiriseiki Hospital Higashiosaka Japan
² Department of Internal Medicine Kansai Medical University Kori Hospital Neyagawa Japan
³ Department of Nephrology and Hypertension Dokkyo Medical University Mibu Japan
⁴ Department of Internal Medicine Daito Central Hospital Daito Japan
⁵ Department of Cardiovascular Medicine Osaka Metropolitan University Graduate School of Medicine Osaka Japan

Abstract

The authors investigated the antihypertensive effect of sacubitril/valsartan (Sac/Val) when switching from other drugs and assessed whether brain natriuretic peptide (BNP) or plasma renin activity (PRA) before drug switching was a predictor of blood pressure lowering after switching to Sac/Val. In 92 patients with treated hypertension, clinic blood pressure, plasma BNP, and PRA were examined before and after switching to Sac/Val. Clinic systolic and diastolic blood pressures...

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The Journal of Clinical Hypertension

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