Carbohydrate antigen 125: a useful marker of congestion, fibrosis, and prognosis in heart failure with preserved ejection fraction

Published on 02/12/2024

Reading time: 6 min.

Nassiba Menghoum^1,2, Maria Chiara Badii^1,2, Matthieu Deltombe³, Sibille Lejeune^1,2, Clotilde Roy¹, David Vancraeynest^1,2, Agnes Pasquet^1,2, Bernhard L. Gerber^1,2, Sandrine Horman², Damien Gruson³, Christophe Beauloye^1,2, Anne‐Catherine Pouleur ^1,2

¹ Cardiovascular Department Cliniques universitaires Saint‐Luc Brussels Belgium
² Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC) Université Catholique de Louvain (UCLouvain) Brussels Belgium
³ Department of Laboratory Medicine Cliniques universitaires Saint‐Luc Brussels Belgium

Abstract

Aims Heart failure (HF) with preserved ejection fraction (HFpEF) is a disease associated with high morbidity and mortality, for which it is difficult to identify patients with the poorest prognosis in routine clinical practice. Carbohydrate antigen 125 (CA 125) has been shown to be a potential marker of congestion and prognosis in HF. We sought to better characterize HFpEF patients with high CA 125 levels by using a multimodal approach.
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